Phenytoin (All indications) updated on 04-22-2025

Cognitive developmental disorders/delay (3-6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9266
R48807		 Meador (Phenytoin), 2013 IQ <85 (DAS) (at 4.5 years old) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: Yes 1.15 [0.30;4.31] C 4/43   6/73 10 43
ref
Total 1 studies 1.15 [0.30;4.31] 10 43
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meador (Phenytoin), 2013Meador, 2013 1 1.15[0.30; 4.31]10430%ROB confusion: moderateROB selection: lowROB classification: lowROB missing: moderateROB mesure: lowROB reporting: low0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.15[0.30; 4.31]1043 -NAMeador (Phenytoin), 2013 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 1.15[0.30; 4.31]1043 -NAMeador (Phenytoin), 2013 1 Tags Adjustment   - Yes  - Yes 1.15[0.30; 4.31]1043 -NAMeador (Phenytoin), 2013 1 All studiesAll studies 1.15[0.30; 4.31]1043 -NAMeador (Phenytoin), 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.15[0.30; 4.31]1043 -NAMeador (Phenytoin), 2013 10.510.01.0