Phenytoin (All indications) updated on 04-22-2025

Chromosomal abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9224
R32013		 Artama (Phenytoin), 2005 Chromosomal anomalies 1st trimester retrospective cohort (registry) unexposed, sick Adjustment: No 25.03 [0.49;1278.58] C 0/38   0/939 0 38
ref
Total 1 studies 25.03 [0.49;1278.58] 0 38
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Phenytoin), 2005Artama, 2005 1 25.03[0.49; 1278.58]0380%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 25.03[0.49; 1278.58]-38 -NAArtama (Phenytoin), 2005 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 25.03[0.49; 1278.58]-38 -NAArtama (Phenytoin), 2005 1 Tags Adjustment   - No  - No 25.03[0.49; 1278.58]-38 -NAArtama (Phenytoin), 2005 1 All studiesAll studies 25.03[0.49; 1278.58]-38 -NAArtama (Phenytoin), 2005 10.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale25.03[0.49; 1278.58]-38 -NAArtama (Phenytoin), 2005 10.510.01.0