Valproate (All indications) updated on 04-22-2025

Fetal distress

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9450
R33183		 Rihtman (Valproate) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2013 Fetal distress during labor at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Controls: epilepsy indication 1.46 [0.34;6.38] C
excluded (control group) 		4/30   4/42 8 30
ref
S9451
R33218		 Rihtman (Valproate) (Controls unexposed, NOS) (Mixed indications), 2013 Fetal distress during labor at least 1st trimester excluded prospective cohort unexposed (general population or NOS) Adjustment: No 0.99 [0.26;3.70] C
excluded (exposition period) 		4/30   7/52 11 30
ref
S9411
R32995		 McVearry (Valproate), 2009 Fetal distress during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 0.09 [0.00;1.83] C 0/16   4/17 4 16
ref
S9308
R32417		 Jäger-Roman (Valproate), 1986 Distressed infants (during labor) (i.e., fetal heart tones with late decelerations, silent or accelerated beat-to-beat variations) at least 1st trimester excluded prospective cohort unexposed (general population or NOS) Adjustment: No 9.00 [1.50;53.86] C
excluded (exposition period) 		6/14   2/26 8 14
ref
Total 1 studies 0.09 [0.00;1.83] 4 16
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF McVearry (Valproate), 2009McVearry, 2009 1 0.09[0.00; 1.83]4160%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.09[0.00; 1.83]416 -NAMcVearry (Valproate), 2009 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.09[0.00; 1.83]416 -NAMcVearry (Valproate), 2009 1 Tags Adjustment   - No  - No 0.09[0.00; 1.83]416 -NAMcVearry (Valproate), 2009 1 All studiesAll studies 0.09[0.00; 1.83]416 -NAMcVearry (Valproate), 2009 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9450

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.09[0.00; 1.83]416 -NAMcVearry (Valproate), 2009 10.510.01.0