Valproate (All indications) - Medication and Pregnancy KB

Valproate (All indications) updated on 04-22-2025

Pulmonary valve stenosis

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S19424 R82741	Kim (Controls exposed to LTG) (Valproate) (Indications NOS), 2026	Pulmonary valve stenosis	1st trimester	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	4.33 [0.48;38.80] ^C excluded (control group)	4/667 1/718	5	667		ref
S19425 R82752	Kim (Controls unexposed, NOS) (Valproate) (Indications NOS), 2026	Pulmonary valve stenosis	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes	2.96 [0.91;9.65]	4/667 4,047/2,489,078	4,051	667		ref
					Total	1 studies	2.96 [0.91;9.64]		4,051	667
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, NOS) (Valproate) (Indications NOS;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 19424