Valproate (All indications) updated on 04-22-2025

Polyhydramnios

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9300
R32374		 Endo (Valproate) (Controls unexposed, disease free), 2004 Hydramnion at least 1st trimester retrospective cohort unexposed, disease free excluded Adjustment: No 8.46 [0.42;169.86] C
excluded (control group) 		0/5   8/656 8 5
ref
S9301
R32389		 Endo (Valproate) (Controls unexposed, sick), 2004 Hydramnion throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 0.11 [0.00;14.76] C 0/5   0/1 0 5
ref
Total 1 studies 0.11 [0.00;14.76] 0 5
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Endo (Valproate) (Controls unexposed, sick), 2004Endo, 2004 1 0.11[0.00; 14.76]050%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.11[0.00; 14.76]-5 -NAEndo (Valproate) (Controls unexposed, sick), 2004 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.11[0.00; 14.76]-5 -NAEndo (Valproate) (Controls unexposed, sick), 2004 1 Tags Adjustment   - No  - No 0.11[0.00; 14.76]-5 -NAEndo (Valproate) (Controls unexposed, sick), 2004 1 All studiesAll studies 0.11[0.00; 14.76]-5 -NAEndo (Valproate) (Controls unexposed, sick), 2004 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9300

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 8.46[0.42; 169.86]85 -NAEndo (Valproate) (Controls unexposed, disease free), 2004 1 unexposed, sick controlsunexposed, sick controls Out of scale0.11[0.00; 14.76]-5 -NAEndo (Valproate) (Controls unexposed, sick), 2004 10.510.01.0