Valproate (All indications) - Medication and Pregnancy KB

Valproate (All indications) updated on 04-22-2025

Abruptio placentae (retroplacental hematoma)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S9315 R32454	Cohen (Valproate) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019	Placental abruption	early pregnancy	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: Yes	1.03 [0.53;1.99] excluded (control group)	53/2,398 50/2,682	103	2,398		ref
S9316 R32461	Cohen (Valproate) (Controls unexposed NOS) (Mixed indications), 2019	Placental abruption	early pregnancy	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes	1.25 [0.94;1.66]	53/2,398 20,269/1,440,631	20,322	2,398		ref
					Total	1 studies	1.25 [0.94;1.66]		20,322	2,398
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Valproate) (Controls unexposed NOS) (Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9315