Valproate (All indications) updated on 04-22-2025

Amniotic fluid problems (polyhydramnios and/or oligohydramnios)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9287
R32248		 Aydin (Valproate) (Controls exposed to Lamotrigine, sick), 2020 Amniotic fluid problems (polyhydramnios/oligohydramnios) throughout pregnancy retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.62 [0.01;35.19] C
excluded (control group) 		0/11   0/7 0 11
ref
S9288
R32258		 Aydin (Valproate) (Controls unexposed, sick), 2020 Amniotic fluid problems (polyhydramnios/oligohydramnios) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 2.05 [0.04;110.56] C 0/11   0/22 0 11
ref
Total 1 studies 2.05 [0.04;110.56] 0 11
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Aydin (Valproate) (Controls unexposed, sick), 2020Aydin, 2020 1 2.05[0.04; 110.56]0110%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.05[0.04; 110.56]-11 -NAAydin (Valproate) (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.05[0.04; 110.56]-11 -NAAydin (Valproate) (Controls unexposed, sick), 2020 1 Tags Adjustment   - No  - No 2.05[0.04; 110.56]-11 -NAAydin (Valproate) (Controls unexposed, sick), 2020 1 All studiesAll studies 2.05[0.04; 110.56]-11 -NAAydin (Valproate) (Controls unexposed, sick), 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9287

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.05[0.04; 110.56]-11 -NAAydin (Valproate) (Controls unexposed, sick), 2020 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.62[0.01; 35.19]-11 -NAAydin (Valproate) (Controls exposed to Lamotrigine, sick), 2020 10.510.01.0