Valproate (All indications) updated on 04-22-2025

Chromosomal abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17499
R73527		 Wiggs (Epilepsy) (Valproate), 2024 Chromosomal abnormality early pregnancy population based cohort retrospective unexposed, sick Adjustment: Yes 1.88 [0.38;9.26] -/624   -/12,666 - 624
ref
S9330
R32548		 Artama (Valproate), 2005 Chromosomal anomalies 1st trimester retrospective cohort (registry) unexposed, sick Adjustment: No 10.77 [0.44;265.09] C 1/263   0/939 1 263
ref
Total 2 studies 2.66 [0.64;11.11] 1 887
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wiggs (Epilepsy) (Valproate), 2024Wiggs, 2024 1 1.88[0.38; 9.26]-62480%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Artama (Valproate), 2005Artama, 2005 2 10.77[0.44; 265.09]126320%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 2.66[0.64; 11.11]18870.550.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Valproate; 2: Valproate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.66[0.64; 11.11]18870%NAWiggs (Epilepsy) (Valproate), 2024 Artama (Valproate), 2005 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.66[0.64; 11.11]18870%NAWiggs (Epilepsy) (Valproate), 2024 Artama (Valproate), 2005 2 Tags Adjustment   - No  - No 10.77[0.44; 265.09]1263 -NAArtama (Valproate), 2005 1   - Yes  - Yes 1.88[0.38; 9.28]-624 -NAWiggs (Epilepsy) (Valproate), 2024 1 All studiesAll studies 2.66[0.64; 11.11]18870%NAWiggs (Epilepsy) (Valproate), 2024 Artama (Valproate), 2005 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.66[0.64; 11.11]18870%NAWiggs (Epilepsy) (Valproate), 2024 Artama (Valproate), 2005 20.510.01.0