Valproate (All indications) updated on 04-22-2025

Very low birth weight (< 1500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9441
R33154		 Wen (Valproate) (Mixed indications), 2017 Very low birth weight ( 1000 - 1500 g) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 0.63 [0.09;4.51] C 1/226   308/43,956 309 226
ref
Total 1 studies 0.63 [0.09;4.51] 309 226
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wen (Valproate) (Mixed indications), 2017Wen, 2017 1 0.63[0.09; 4.51]3092260%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.63[0.09; 4.51]309226 -NAWen (Valproate) (Mixed indications), 2017 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.63[0.09; 4.51]309226 -NAWen (Valproate) (Mixed indications), 2017 1 Tags Adjustment   - No  - No 0.63[0.09; 4.51]309226 -NAWen (Valproate) (Mixed indications), 2017 1 All studiesAll studies 0.63[0.09; 4.51]309226 -NAWen (Valproate) (Mixed indications), 2017 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.63[0.09; 4.51]309226 -NAWen (Valproate) (Mixed indications), 2017 10.510.01.0