Primidone (All indications)

Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9455
R33263		 Burja (Primidone) (Controls unexposed, disease free), 2006 Withdrawal symptoms during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, disease free excluded Adjustment: No 421.00 [3.45;51304.46] C
excluded (control group) 		0/1   0/211 0 1
ref
S9456
R33268		 Burja (Primidone) (Controls unexposed, sick), 2006 Withdrawal symptoms during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, sick Adjustment: No 63.00 [0.51;7760.63] C 0/1   0/32 0 1
ref
S9457
R33272		 Dean (Primidone), 2002 Neonatal withdrawal features at least 1st trimester excluded retrospective cohort unexposed, sick Adjustment: No 8.11 [0.22;294.82] C
excluded (exposition period) 		0/2   1/38 1 2
ref
Total 1 studies 63.00 [0.51;7760.63] 0 1
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Burja (Primidone) (Controls unexposed, sick), 2006Burja, 2006 1 63.00[0.51; 7760.63]010%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.9500.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Primidone) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 63.00[0.51; 7760.63]-1 -NABurja (Primidone) (Controls unexposed, sick), 2006 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 63.00[0.51; 7760.63]-1 -NABurja (Primidone) (Controls unexposed, sick), 2006 1 Tags Adjustment   - No  - No 63.00[0.51; 7760.63]-1 -NABurja (Primidone) (Controls unexposed, sick), 2006 1 All studiesAll studies 63.00[0.51; 7760.63]-1 -NABurja (Primidone) (Controls unexposed, sick), 2006 10.51000.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9455

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale421.00[3.45; 51304.46]-1 -NABurja (Primidone) (Controls unexposed, disease free), 2006 1 unexposed, sick controlsunexposed, sick controls Out of scale63.00[0.51; 7760.63]-1 -NABurja (Primidone) (Controls unexposed, sick), 2006 10.510.01.0