Primidone (All indications)

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9481
R33340		 Kilic (Primidone) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.91 [0.12;6.93] C
excluded (control group) 		1/20   48/876 49 20
ref
S9482
R33343		 Kilic (Primidone) (Controls unexposed NOS) (Mixed indications), 2014 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: No 1.46 [0.19;10.88] C
excluded (control group) 		1/20   23,503/673,844 23,504 20
ref
S9483
R33346		 Kilic (Primidone) (Controls unexposed, sick) (Mixed indications), 2014 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No Controls: epilepsy indication 1.06 [0.14;7.97] C 1/20   249/5,275 250 20
ref
Total 1 studies 1.06 [0.14;7.97] 250 20
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kilic (Primidone) (Controls unexposed, sick) (Mixed indications), 2014Kilic, 2014 1 1.06[0.14; 7.97]250200%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Primidone) (Controls unexposed, sick) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.06[0.14; 7.97]25020 -NAKilic (Primidone) (Controls unexposed, sick) (Mixed indications), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.06[0.14; 7.97]25020 -NAKilic (Primidone) (Controls unexposed, sick) (Mixed indications), 2014 1 Tags Adjustment   - No  - No 1.06[0.14; 7.97]25020 -NAKilic (Primidone) (Controls unexposed, sick) (Mixed indications), 2014 1 Controls   - epilepsy indication  - epilepsy indication 1.06[0.14; 7.97]25020 -NAKilic (Primidone) (Controls unexposed, sick) (Mixed indications), 2014 1 All studiesAll studies 1.06[0.14; 7.97]25020 -NAKilic (Primidone) (Controls unexposed, sick) (Mixed indications), 2014 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9481, 9482

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.46[0.19; 10.88]23,50420 -NAKilic (Primidone) (Controls unexposed NOS) (Mixed indications), 2014 1 unexposed, sick controlsunexposed, sick controls 1.06[0.14; 7.97]25020 -NAKilic (Primidone) (Controls unexposed, sick) (Mixed indications), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.91[0.12; 6.93]4920 -NAKilic (Primidone) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 10.510.01.0