Primidone AND Phenobarbital (All indications) - Medication and Pregnancy KB

Primidone AND Phenobarbital (All indications) updated on 04-22-2025

Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S9570 R33892	Burja (Phenobarbital or Primidone) (Controls unexposed, disease free), 2006	Withdrawal symptoms	during pregnancy (anytime or not specified)	retrospective cohort (registry)	unexposed, disease free excluded	Adjustment: No	140.33 [2.03;9703.67] ^C excluded (control group)	0/2 0/211	0	2		ref
S9568 R33882	Burja (Phenobarbital or Primidone) (Controls unexposed, sick), 2006	Withdrawal symptoms	during pregnancy (anytime or not specified)	retrospective cohort (registry)	unexposed, sick	Adjustment: No	21.00 [0.30;1469.95] ^C	0/2 0/32	0	2		ref
S9571 R33896	Dean (Phenobarbital or Primidone), 2002	Neonatal withdrawal features	at least 1st trimester excluded	retrospective cohort	unexposed, sick	Adjustment: No	5.38 [0.65;44.85] ^C excluded (exposition period)	8/63 1/38	9	63		ref
					Total	1 studies	21.00 [0.30;1469.95]		0	2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Phenobarbital or Primidone) (Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9570