Primidone AND Phenobarbital (All indications) - Medication and Pregnancy KB

Primidone AND Phenobarbital (All indications) updated on 04-22-2025

Atrial septal defect

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S10043 R36318	Blotière (Phenobarbital) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019	Atrial septal defect	1st trimester	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No	2.21 [0.13;38.65] ^C excluded (control group)	0/80 8/2,997	8	80		ref
S10044 R36341	Blotière (Phenobarbital) (Controls unexposed NOS) (Mixed indications), 2019	Atrial septal defect	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No	3.60 [0.22;58.12] ^C	0/80 3,268/1,875,733	3,268	80		ref
					Total	1 studies	3.60 [0.22;58.12]		3,268	80
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Phenobarbital) (Controls unexposed NOS) (Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10043