Primidone AND Phenobarbital (All indications) updated on 04-22-2025

Eye deficiency / Visual abnormality

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9559
R33813		 Shankaran (Phenobarbital) (Other indications), 2002 Bilateral blindness days before delivery randomized controlled trial unexposed, sick Adjustment: Randomisation 2.66 [0.27;25.79] C 3/224   1/197 4 224
ref
Total 1 studies 2.66 [0.27;25.79] 4 224
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Shankaran (Phenobarbital) (Other indications), 2002Shankaran, 2002 1 2.66[0.27; 25.79]42240%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital) (Other indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 2.66[0.27; 25.79]4224 -NAShankaran (Phenobarbital) (Other indications), 2002 1 Type of controls unexposed, sickunexposed, sick 2.66[0.27; 25.79]4224 -NAShankaran (Phenobarbital) (Other indications), 2002 1 Tags Adjustment   - Randomisation  - Randomisation 2.66[0.27; 25.79]4224 -NAShankaran (Phenobarbital) (Other indications), 2002 1 All studiesAll studies 2.66[0.27; 25.79]4224 -NAShankaran (Phenobarbital) (Other indications), 2002 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.66[0.27; 25.79]4224 -NAShankaran (Phenobarbital) (Other indications), 2002 10.510.01.0