Carbamazepine (All indications) updated on 04-22-2025

Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9606
R34059		 Burja (Carbamazepine) (Controls unexposed, disease free), 2006 Withdrawal symptoms during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, disease free excluded Adjustment: No 11.38 [0.22;590.18] C
excluded (control group) 		0/19   0/211 0 19
ref
S9607
R34064		 Burja (Carbamazepine) (Controls unexposed, sick), 2006 Withdrawal symptoms during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, sick Adjustment: No 1.70 [0.03;89.48] C 0/19   0/32 0 19
ref
S9614
R34146		 Dean (Carbamazepine), 2002 Neonatal withdrawal features at least 1st trimester excluded retrospective cohort unexposed, sick Adjustment: No 6.27 [0.77;51.03] C
excluded (exposition period) 		10/69   1/38 11 69
ref
Total 1 studies 1.70 [0.03;89.48] 0 19
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Burja (Carbamazepine) (Controls unexposed, sick), 2006Burja, 2006 1 1.70[0.03; 89.48]0190%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.70[0.03; 89.48]-19 -NABurja (Carbamazepine) (Controls unexposed, sick), 2006 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.70[0.03; 89.48]-19 -NABurja (Carbamazepine) (Controls unexposed, sick), 2006 1 Tags Adjustment   - No  - No 1.70[0.03; 89.48]-19 -NABurja (Carbamazepine) (Controls unexposed, sick), 2006 1 All studiesAll studies 1.70[0.03; 89.48]-19 -NABurja (Carbamazepine) (Controls unexposed, sick), 2006 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9606

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale11.38[0.22; 590.18]-19 -NABurja (Carbamazepine) (Controls unexposed, disease free), 2006 1 unexposed, sick controlsunexposed, sick controls 1.70[0.03; 89.48]-19 -NABurja (Carbamazepine) (Controls unexposed, sick), 2006 10.510.01.0