Carbamazepine (All indications) updated on 04-22-2025

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9663
R34407		 Holmes (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2011 Neonatal death (first 28 days of life) 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Controls: mixed indications 2.77 [0.66;11.65] C
excluded (control group) 		5/573   3/948 8 573
ref
S9675
R34444		 Holmes (Carbamazepine) (Controls unexposed, disease free), 2011 Neonatal death 1st trimester prospective cohort unexposed, disease free Adjustment: No 1.66 [0.19;14.33] C 5/573   1/190 6 573
ref
Total 1 studies 1.66 [0.19;14.33] 6 573
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Holmes (Carbamazepine) (Controls unexposed, disease free), 2011Holmes, 2011 1 1.66[0.19; 14.33]65730%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.66[0.19; 14.33]6573 -NAHolmes (Carbamazepine) (Controls unexposed, disease free), 2011 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.66[0.19; 14.33]6573 -NAHolmes (Carbamazepine) (Controls unexposed, disease free), 2011 1 Tags Adjustment   - No  - No 1.66[0.19; 14.33]6573 -NAHolmes (Carbamazepine) (Controls unexposed, disease free), 2011 1 All studiesAll studies 1.66[0.19; 14.33]6573 -NAHolmes (Carbamazepine) (Controls unexposed, disease free), 2011 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9663

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.66[0.19; 14.33]6573 -NAHolmes (Carbamazepine) (Controls unexposed, disease free), 2011 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.77[0.66; 11.65]8573 -NAHolmes (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2011 10.510.01.0