Ethosuximide (All indications) updated on 04-22-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9792
R35057		 Kilic (Ethosuximide) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 Preterm (< 37 weeks) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 9.54 [0.19;483.89] C
excluded (control group) 		0/1   83/880 83 1
ref
S9793
R35060		 Kilic (Ethosuximide) (Controls unexposed NOS) (Mixed indications), 2014 Preterm (< 37 weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: No 18.92 [0.38;953.68] C
excluded (control group) 		0/1   33,974/676,834 33,974 1
ref
S9794
R35063		 Kilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 Preterm (< 37 weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No Controls: epilepsy indication 12.81 [0.25;646.50] C 0/1   383/5,296 383 1
ref
Total 1 studies 12.81 [0.25;646.50] 383 1
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014Kilic, 2014 1 12.81[0.25; 646.50]38310%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Ethosuximide) (Controls unexposed, sick) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 12.81[0.25; 646.50]3831 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 12.81[0.25; 646.50]3831 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 1 Tags Adjustment   - No  - No 12.81[0.25; 646.50]3831 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 1 Controls   - epilepsy indication  - epilepsy indication 12.81[0.25; 646.50]3831 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 1 All studiesAll studies 12.81[0.25; 646.50]3831 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9792, 9793

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale18.92[0.38; 953.68]33,9741 -NAKilic (Ethosuximide) (Controls unexposed NOS) (Mixed indications), 2014 1 unexposed, sick controlsunexposed, sick controls Out of scale12.81[0.25; 646.50]3831 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 9.54[0.19; 483.89]831 -NAKilic (Ethosuximide) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Veroniki a (NMA) (All indications) (Preterm birth)Veroniki a (NMA) (All indications) (Preterm birth) 1.07[0.04; 6.87]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg Out of scale12.81[0.25; 646.50]NaN%1----Kilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 10.510.01.0