Ethosuximide (All indications) updated on 04-22-2025

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9792
R35055		 Kilic (Ethosuximide) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 17.06 [0.33;869.16] C
excluded (control group) 		0/1   48/876 48 1
ref
S9793
R35058		 Kilic (Ethosuximide) (Controls unexposed NOS) (Mixed indications), 2014 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: No 27.67 [0.55;1394.61] C
excluded (control group) 		0/1   23,503/673,844 23,503 1
ref
S9794
R35061		 Kilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No Controls: epilepsy indication 20.14 [0.40;1017.27] C 0/1   249/5,275 249 1
ref
Total 1 studies 20.14 [0.40;1017.27] 249 1
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014Kilic, 2014 1 20.14[0.40; 1017.27]24910%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Ethosuximide) (Controls unexposed, sick) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 20.14[0.40; 1017.27]2491 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 20.14[0.40; 1017.27]2491 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 1 Tags Adjustment   - No  - No 20.14[0.40; 1017.27]2491 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 1 Controls   - epilepsy indication  - epilepsy indication 20.14[0.40; 1017.27]2491 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 1 All studiesAll studies 20.14[0.40; 1017.27]2491 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9792, 9793

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale27.67[0.55; 1394.61]23,5031 -NAKilic (Ethosuximide) (Controls unexposed NOS) (Mixed indications), 2014 1 unexposed, sick controlsunexposed, sick controls Out of scale20.14[0.40; 1017.27]2491 -NAKilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale17.06[0.33; 869.16]481 -NAKilic (Ethosuximide) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 10.510.01.0