Zonisamide (All indications) updated on 04-22-2025

Language disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12806
R48229		 Meador (Zonisamide) (Controls exposed to Lamotrigine, sick), 2021 Language Score in 2 years old children with the Bayley Scales of Infant and Toddler Development (BSID-III) 3rd trimester prospective cohort exposed to other treatment, sick excluded Adjustment: Yes extrapolated (cont. endpoint) 0.33 [0.11;1.04]
excluded (control group) 		-/11   -/93 - 11
ref
S12807
R48230		 Meador (Zonisamide) (Controls unexposed, disease free), 2021 Language Score in 2 years old children with the Bayley Scales of Infant and Toddler Development (BSID-III) 3rd trimester prospective cohort unexposed, disease free Adjustment: Yes extrapolated (cont. endpoint) 0.33 [0.10;1.04] -/11   -/87 - 11
ref
Total 1 studies 0.33 [0.10;1.06] 0 11
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meador (Zonisamide) (Controls unexposed, disease free), 2021Meador, 2021 1 0.33[0.10; 1.04]-110%ROB confusion: moderateROB selection: lowROB classification: lowROB missing: moderateROB mesure: moderateROB reporting: low0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Zonisamide) (Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.33[0.10; 1.06]-11 -NAMeador (Zonisamide) (Controls unexposed, disease free), 2021 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.33[0.10; 1.06]-11 -NAMeador (Zonisamide) (Controls unexposed, disease free), 2021 1 Tags Adjustment   - Yes  - Yes 0.33[0.10; 1.06]-11 -NAMeador (Zonisamide) (Controls unexposed, disease free), 2021 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 0.33[0.10; 1.06]-11 -NAMeador (Zonisamide) (Controls unexposed, disease free), 2021 1 All studiesAll studies 0.33[0.10; 1.06]-11 -NAMeador (Zonisamide) (Controls unexposed, disease free), 2021 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12806

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.33[0.10; 1.06]-11 -NAMeador (Zonisamide) (Controls unexposed, disease free), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.33[0.11; 1.01]-11 -NAMeador (Zonisamide) (Controls exposed to Lamotrigine, sick), 2021 10.510.01.0