Zonisamide (All indications) updated on 04-22-2025

Learning disorders

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S19384
R82311		 Straub (Controls exposed to LTG) (Zonisamide) (Epilepsy), 2026 Learning difficulty - ICD-10 codes: F81.0, F81.2, F81.8x, R48.0 - Mean follow up (full cohort): 3.4 years during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No 0.53 [0.03;9.00] C 0/246   12/3,273 12 246
ref
Total 1 studies 0.53 [0.03;9.00] 12 246
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Straub (Controls exposed to LTG) (Zonisamide) (Epilepsy), 2026Straub, 2026 1 0.53[0.03; 9.00]122460%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls exposed to LTG) (Zonisamide) (Epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.53[0.03; 9.00]12246 -NAStraub (Controls exposed to LTG) (Zonisamide) (Epilepsy), 2026 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.53[0.03; 9.00]12246 -NAStraub (Controls exposed to LTG) (Zonisamide) (Epilepsy), 2026 1 Tags Adjustment   - No  - No 0.53[0.03; 9.00]12246 -NAStraub (Controls exposed to LTG) (Zonisamide) (Epilepsy), 2026 1 All studiesAll studies 0.53[0.03; 9.00]12246 -NAStraub (Controls exposed to LTG) (Zonisamide) (Epilepsy), 2026 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.53[0.03; 9.00]12246 -NAStraub (Controls exposed to LTG) (Zonisamide) (Epilepsy), 2026 10.510.01.0