Zonisamide (All indications) updated on 04-22-2025

ASD (Autism spectrum disorder): Diagnosis/Risk

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S19375
R82478		 Straub (Controls unexposed, sick) (Zonisamide) (Epilepsy), 2026 Autism spectrum disorder - ICD-10 codes: F84.x (except F84.2, F84.3) - Mean follow up (full cohort): 3.4 years during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 0.92 [0.28;2.97] -/246   106/8,887 - 246
ref
Total 1 studies 0.92 [0.28;3.00] 0 246
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Straub (Controls unexposed, sick) (Zonisamide) (Epilepsy), 2026Straub, 2026 1 0.92[0.28; 2.97]-2460%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick) (Zonisamide) (Epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.92[0.28; 3.00]-246 -NAStraub (Controls unexposed, sick) (Zonisamide) (Epilepsy), 2026 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.92[0.28; 3.00]-246 -NAStraub (Controls unexposed, sick) (Zonisamide) (Epilepsy), 2026 1 Tags Adjustment   - Yes  - Yes 0.92[0.28; 3.00]-246 -NAStraub (Controls unexposed, sick) (Zonisamide) (Epilepsy), 2026 1 All studiesAll studies 0.92[0.28; 3.00]-246 -NAStraub (Controls unexposed, sick) (Zonisamide) (Epilepsy), 2026 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.92[0.28; 3.00]97246 -NAStraub (Controls unexposed, sick) (Zonisamide) (Epilepsy), 2026 10.510.01.0