Zonisamide (All indications) updated on 04-22-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10204
R37392		 Hernández-Díaz (Zonisamide) (Controls exposed to Lamotrigine, sick), 2014 Preterm (< 37 weeks) throughout pregnancy prospective cohort exposed to other treatment, sick excluded Adjustment: No Controls: mixed indications 1.40 [0.71;2.76] C
excluded (control group) 		10/98   119/1,581 129 98
ref
S10205
R37394		 Hernández-Díaz (Zonisamide) (Controls unexposed, disease free), 2014 Preterm (< 37 weeks) throughout pregnancy prospective cohort unexposed, disease free Adjustment: No 1.81 [0.85;3.87] C 10/98   27/457 37 98
ref
Total 1 studies 1.81 [0.85;3.87] 37 98
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hernández-Díaz (Zonisamide) (Controls unexposed, disease free), 2014Hernández-Díaz, 2014 1 1.81[0.85; 3.87]37980%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Zonisamide) (Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.81[0.85; 3.87]3798 -NAHernández-Díaz (Zonisamide) (Controls unexposed, disease free), 2014 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.81[0.85; 3.87]3798 -NAHernández-Díaz (Zonisamide) (Controls unexposed, disease free), 2014 1 Tags Adjustment   - No  - No 1.81[0.85; 3.87]3798 -NAHernández-Díaz (Zonisamide) (Controls unexposed, disease free), 2014 1 All studiesAll studies 1.81[0.85; 3.87]3798 -NAHernández-Díaz (Zonisamide) (Controls unexposed, disease free), 2014 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10204

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.81[0.85; 3.87]3798 -NAHernández-Díaz (Zonisamide) (Controls unexposed, disease free), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.40[0.71; 2.76]12998 -NAHernández-Díaz (Zonisamide) (Controls exposed to Lamotrigine, sick), 2014 10.510.01.0