Triptans

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3510
R6904
Spielmann (Control mainly exposed other treatments, sick), 2017 Preeclampsia during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: Yes 1.54 [0.60;4.10]
excluded (control group)
16/322   15/386 31 322
ref
S3509
R6905
Spielmann (Control unexposed, disease free), 2017 Preeclampsia during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: Yes 1.33 [0.70;2.50] 16/322   60/1,343 76 322
ref
S3535
R6991
Wood 2016a (Control exposed only before pregnancy), 2016 Pre-eclampsia during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 1.91 [1.15;3.15] C 31/396   34/798 65 396
ref
S3539
R7007
Wood 2016a (Control mainly exposed to other treatments, sick), 2016 Pre-eclampsia during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: Yes 2.03 [1.35;3.05] C
excluded (control group)
31/396   132/3,291 163 396
ref
S3538
R6998
Wood 2016a (Control unexposed, disease free), 2016 Pre-eclampsia during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No 2.34 [1.62;3.39] C
excluded (control group)
31/396   1,284/36,688 1,315 396
ref
S3492
R6761
Nezvalová-Henriksen (Control unexposed, disease free), 2013 Preeclampsia and/or eclampsia during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: No 1.36 [1.07;1.73] C
excluded (control group)
71/1,465   6,449/178,565 6,520 1,465
ref
S851
R6742
Nezvalová-Henriksen (Control unexposed, sick), 2013 Preeclampsia and/or eclampsia during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 0.83 [0.59;1.18] C 71/1,465   63/1,095 134 1,465
ref
Total 3 studies 1.25 [0.73;2.14] 275 2,183
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Spielmann (Control unexposed, disease free), 2017Spielmann, 2017 1 1.33[0.70; 2.50]7632228%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Wood 2016a (Control exposed only before pregnancy), 2016Wood 2016a, 2016 2 1.91[1.15; 3.15]6539633%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Nezvalová-Henriksen (Control unexposed, sick), 2013Nezvalová-Henriksen, 2013 3 0.83[0.59; 1.18]1341,46539%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 73% 1.25[0.73; 2.14]2752,1830.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, disease free; 2: Control exposed only before pregnancy; 3: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.25[0.73; 2.14]2752,18373%NASpielmann (Control unexposed, disease free), 2017 Wood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.33[0.70; 2.51]76322 -NASpielmann (Control unexposed, disease free), 2017 1 unexposed, sickunexposed, sick 1.24[0.55; 2.78]1991,86186%NAWood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 2 Tags Adjustment   - No  - No 1.24[0.55; 2.78]1991,86186%NAWood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 2   - Yes  - Yes 1.33[0.70; 2.51]76322 -NASpielmann (Control unexposed, disease free), 2017 1 All studiesAll studies 1.25[0.73; 2.14]2752,18373%NASpielmann (Control unexposed, disease free), 2017 Wood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3492, 3539, 3538, 3510

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.64[1.11; 2.42]7,9112,18367%NASpielmann (Control unexposed, disease free), 2017 Wood 2016a (Control unexposed, disease free), 2016 Nezvalová-Henriksen (Control unexposed, disease free), 2013 3 unexposed, sick controlsunexposed, sick controls 1.24[0.55; 2.78]1991,86186%NAWood 2016a (Control exposed only before pregnancy), 2016 Nezvalová-Henriksen (Control unexposed, sick), 2013 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.95[1.34; 2.83]1947180%NASpielmann (Control mainly exposed other treatments, sick), 2017 Wood 2016a (Control mainly exposed to other treatments, sick), 2016 20.510.01.0