Triptans

Cardiac septal defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S849
R6810		 Källén (control unexposed, disease free), 2011 VSD and/or ASD 1st trimester population based cohort propective unexposed, disease free Adjustment: Yes 1.08 [0.67;1.74] 17/2,777   6,775/1,229,901 6,792 2,777
ref
Total 1 studies 1.08 [0.67;1.74] 6,792 2,777
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Källén (control unexposed, disease free), 2011Källén, 2011 1 1.08[0.67; 1.74]6,7922,7770%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.08[0.67; 1.74]6,7922,777 -NAKällén (control unexposed, disease free), 2011 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.08[0.67; 1.74]6,7922,777 -NAKällén (control unexposed, disease free), 2011 1 Tags Adjustment   - Yes  - Yes 1.08[0.67; 1.74]6,7922,777 -NAKällén (control unexposed, disease free), 2011 1 All studiesAll studies 1.08[0.67; 1.74]6,7922,777 -NAKällén (control unexposed, disease free), 2011 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.08[0.67; 1.74]6,7922,777 -NAKällén (control unexposed, disease free), 2011 10.510.01.0