Triptans

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3535
R6993		 Wood 2016a (Control exposed only before pregnancy), 2016 Apgar 5 (< 7) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 1.52 [0.52;4.41] C 6/396   8/798 14 396
ref
S3539
R7009		 Wood 2016a (Control mainly exposed to other treatments, sick), 2016 Apgar 5 (< 7) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: Yes 1.67 [0.69;4.04] C
excluded (control group) 		6/396   30/3,291 36 396
ref
S3538
R7000		 Wood 2016a (Control unexposed, disease free), 2016 Apgar 5 (< 7) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No 1.70 [0.75;3.82] C
excluded (control group) 		6/396   330/36,688 336 396
ref
Total 1 studies 1.52 [0.52;4.41] 14 396
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wood 2016a (Control exposed only before pregnancy), 2016Wood 2016a, 2016 1 1.52[0.52; 4.41]143960%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control exposed only before pregnancy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.52[0.52; 4.41]14396 -NAWood 2016a (Control exposed only before pregnancy), 2016 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.52[0.52; 4.41]14396 -NAWood 2016a (Control exposed only before pregnancy), 2016 1 Tags Adjustment   - No  - No 1.52[0.52; 4.41]14396 -NAWood 2016a (Control exposed only before pregnancy), 2016 1 All studiesAll studies 1.52[0.52; 4.41]14396 -NAWood 2016a (Control exposed only before pregnancy), 2016 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3539, 3538

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.70[0.75; 3.82]336396 -NAWood 2016a (Control unexposed, disease free), 2016 1 unexposed, sick controlsunexposed, sick controls 1.52[0.52; 4.41]14396 -NAWood 2016a (Control exposed only before pregnancy), 2016 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.67[0.69; 4.04]36396 -NAWood 2016a (Control mainly exposed to other treatments, sick), 2016 10.510.01.0