Triptans

Abruptio placentae (retroplacental hematoma)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3510
R6907		 Spielmann (Control mainly exposed other treatments, sick), 2017 Abruptio placentae during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: Yes 1.86 [0.30;14.00]
excluded (control group) 		5/432   2/475 7 432
ref
S3509
R6906		 Spielmann (Control unexposed, disease free), 2017 Placental abruption during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: Yes 2.80 [0.60;13.10] 5/432   4/1,733 9 432
ref
Total 1 studies 2.80 [0.60;13.08] 9 432
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Spielmann (Control unexposed, disease free), 2017Spielmann, 2017 1 2.80[0.60; 13.10]94320%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.80[0.60; 13.08]9432 -NASpielmann (Control unexposed, disease free), 2017 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.80[0.60; 13.08]9432 -NASpielmann (Control unexposed, disease free), 2017 1 Tags Adjustment   - Yes  - Yes 2.80[0.60; 13.08]9432 -NASpielmann (Control unexposed, disease free), 2017 1 All studiesAll studies 2.80[0.60; 13.08]9432 -NASpielmann (Control unexposed, disease free), 2017 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3510

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.80[0.60; 13.08]9432 -NASpielmann (Control unexposed, disease free), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.86[0.27; 12.71]7432 -NASpielmann (Control mainly exposed other treatments, sick), 2017 10.510.01.0