Triptans

Minor congenital malformations

id	Study   Auto Spielmann (Control mainly exposed other treatments, sick), 2017Spielmann (Control unexposed, disease free), 2017O'Quinn - Sumatriptan, 1999	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3510 R6886	Spielmann (Control mainly exposed other treatments, sick), 2017	Minor birth defects	1st trimester	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	1.23 [0.54;2.83] C excluded (control group)	11/320   12/427	23	320		ref
S3509 R6862	Spielmann (Control unexposed, disease free), 2017	Minor birth defects	1st trimester	prospective cohort	unexposed, disease free	Adjustment: No	1.71 [0.85;3.44] C	11/320   31/1,520	42	320		ref
S3593 R7293	O'Quinn - Sumatriptan, 1999	Minor malformations	1st trimester	prospective cohort	unexposed, sick	Adjustment: No	0.12 [0.01;2.29] C	0/67   4/77	4	67		ref
					Total	2 studies	0.68 [0.06;8.05]		46	387
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 3510