Triptans

Nervous system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3510
R6892		 Spielmann (Control mainly exposed other treatments, sick), 2017 Nervous system during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.59 [0.05;6.51] C
excluded (control group) 		1/364   2/429 3 364
ref
S3509
R6868		 Spielmann (Control unexposed, disease free), 2017 Nervous system during pregnancy (anytime or not specified) excluded prospective cohort unexposed, disease free Adjustment: No 0.60 [0.07;4.86] C
excluded (exposition period) 		1/364   7/1,522 8 364
ref
S3594
R7295		 De Jonge - Sumatriptan, 2013 Central nervous system 1st trimester case control unexposed (general population or NOS) Adjustment: No 1.20 [0.07;19.50] C 0/58   208/29,373 208 58
ref
Total 1 studies 1.20 [0.07;19.50] 208 58
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Jonge - Sumatriptan, 2013De Jonge - Sumatriptan, 2013 1.20[0.07; 19.50]208580%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.20[0.07; 19.50]20858 -NADe Jonge - Sumatriptan, 2013 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[0.07; 19.50]20858 -NADe Jonge - Sumatriptan, 2013 1 Tags Adjustment   - No  - No 1.20[0.07; 19.50]20858 -NADe Jonge - Sumatriptan, 2013 1 All studiesAll studies 1.20[0.07; 19.50]20858 -NADe Jonge - Sumatriptan, 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3510

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[0.07; 19.50]20858 -NADe Jonge - Sumatriptan, 2013 10.510.01.0