Triptans

Digestive system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3509
R6871		 Spielmann (Control unexposed, disease free), 2017 Digestive system during pregnancy (anytime or not specified) excluded prospective cohort unexposed, disease free Adjustment: No 0.84 [0.04;17.44] C
excluded (exposition period) 		0/364   2/1,521 2 364
ref
S3594
R7297		 De Jonge - Sumatriptan, 2013 Digestive system 1st trimester case control unexposed (general population or NOS) Adjustment: No 0.69 [0.04;11.18] C 0/58   362/29,527 362 58
ref
Total 1 studies 0.69 [0.04;11.18] 362 58
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Jonge - Sumatriptan, 2013De Jonge - Sumatriptan, 2013 0.69[0.04; 11.18]362580%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.69[0.04; 11.18]36258 -NADe Jonge - Sumatriptan, 2013 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.69[0.04; 11.18]36258 -NADe Jonge - Sumatriptan, 2013 1 Tags Adjustment   - No  - No 0.69[0.04; 11.18]36258 -NADe Jonge - Sumatriptan, 2013 1 All studiesAll studies 0.69[0.04; 11.18]36258 -NADe Jonge - Sumatriptan, 2013 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.69[0.04; 11.18]36258 -NADe Jonge - Sumatriptan, 2013 10.510.01.0