Triptans

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3510
R6881
Spielmann (Control mainly exposed other treatments, sick), 2017 Stillbirth (>= 23 weeks of gestation or >= 500g) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.10 [0.07;17.64] C
excluded (control group)
1/432   1/475 2 432
ref
S3509
R6857
Spielmann (Control unexposed, disease free), 2017 Stillbirth (>= 23 weeks of gestation or >= 500g) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No 0.80 [0.09;6.88] C 1/432   5/1,733 6 432
ref
S3593
R7291
O'Quinn - Sumatriptan, 1999 Stillbirth (NOS) 1st trimester prospective cohort unexposed, sick Adjustment: No 0.40 [0.02;9.95] C 0/76   1/92 1 76
ref
Total 2 studies 0.65 [0.11;3.86] 7 508
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Spielmann (Control unexposed, disease free), 2017Spielmann, 2017 1 0.80[0.09; 6.88]643269%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA O'Quinn - Sumatriptan, 1999O'Quinn - Sumatriptan, 1999 0.40[0.02; 9.95]17631%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.65[0.11; 3.86]75080.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.65[0.11; 3.86]75080%NASpielmann (Control unexposed, disease free), 2017 O'Quinn - Sumatriptan, 1999 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.80[0.09; 6.88]6432 -NASpielmann (Control unexposed, disease free), 2017 1 unexposed, sickunexposed, sick 0.40[0.02; 9.95]176 -NAO'Quinn - Sumatriptan, 1999 1 Tags Adjustment   - No  - No 0.65[0.11; 3.86]75080%NASpielmann (Control unexposed, disease free), 2017 O'Quinn - Sumatriptan, 1999 2 All studiesAll studies 0.65[0.11; 3.86]75080%NASpielmann (Control unexposed, disease free), 2017 O'Quinn - Sumatriptan, 1999 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3510

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.80[0.09; 6.88]6432 -NASpielmann (Control unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls Out of scale0.40[0.02; 9.95]176 -NAO'Quinn - Sumatriptan, 1999 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.10[0.07; 17.64]2432 -NASpielmann (Control mainly exposed other treatments, sick), 2017 10.510.01.0