Imipramine updated on 07-01-2025

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11192
R41238		 Anderson, 2020 Major birth defects 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: TCA only 0.37 [0.05;2.66] C 2/4   30,628/42,104 30,630 4
ref
S18307
R77099		 Kullander, 1976 Major malformations (gross and insignificant major malfo) 1st trimester nested case control unexposed (general population or NOS) Adjustment: No 2.79 [0.35;22.11] C 1/10   199/5,192 200 10
ref
Total 2 studies 0.99 [0.14;7.09] 30,830 14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.37[0.05; 2.66]30,630451%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Kullander, 1976Kullander, 1976 2.79[0.35; 22.11]2001049%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 47% 0.99[0.14; 7.09]30,830140.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.99[0.14; 7.09]30,8301447%NAAnderson, 2020 Kullander, 1976 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.99[0.14; 7.09]30,8301447%NAAnderson, 2020 Kullander, 1976 2 Tags Adjustment   - No  - No 0.99[0.14; 7.09]30,8301447%NAAnderson, 2020 Kullander, 1976 2 Monotherapy   - TCA only  - TCA only 0.37[0.05; 2.66]30,6304 -NAAnderson, 2020 1 All studiesAll studies 0.99[0.14; 7.09]30,8301447%NAAnderson, 2020 Kullander, 1976 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.99[0.14; 7.09]30,8301447%NAAnderson, 2020 Kullander, 1976 20.510.01.0