Amitriptyline updated on 07-01-2025

Cognitive developmental disorders/delay (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18375
R77509		 Heuvelman, 2023 Intellectual disability - Validated Read code list among primary care clinical and referral records - Mean age at end of follow-up 10.04 years, range 4–22 years during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.00 [0.39;2.58] -/1,040   -/16,330 - 1,040
ref
Total 1 studies 1.00 [0.39;2.57] 0 1,040
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Heuvelman, 2023Heuvelman, 2023 1.00[0.39; 2.58]-1,0400%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: criticalROB mesure: criticalROB reporting: low0.52.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.00[0.39; 2.57]-1,040 -NAHeuvelman, 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.00[0.39; 2.57]-1,040 -NAHeuvelman, 2023 1 Tags Adjustment   - Yes  - Yes 1.00[0.39; 2.57]-1,040 -NAHeuvelman, 2023 1 Monotherapy   - no or not specified  - no or not specified 1.00[0.39; 2.57]-1,040 -NAHeuvelman, 2023 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.00[0.39; 2.57]-1,040 -NAHeuvelman, 2023 1 All studiesAll studies 1.00[0.39; 2.57]-1,040 -NAHeuvelman, 2023 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.00[0.39; 2.57]-1,040 -NAHeuvelman, 2023 10.510.01.0