Amitriptyline - Medication and Pregnancy KB

Amitriptyline updated on 07-01-2025

Low birth weight (< 2500g)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18423 R77975	Lee (Controls exposed to SSRI), 2025	Low birth weight (birth weight <2500 g)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.03 [0.68;1.55] ^C excluded (control group)	31/301 147/1,465	178	301		ref
S18411 R77760	Lee (Controls unexposed, general pop), 2025	Low birth weight (birth weight <2500 g)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.11 [0.76;1.61]	31/301 31,347/463,440	31,378	301		ref
					Total	1 studies	1.11 [0.76;1.62]		31,378	301
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, general pop;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18423