Nortriptyline - Medication and Pregnancy KB

Nortriptyline updated on 07-01-2025

Child/Infant death (> 28 days of life)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18443 R78304	Lee (Controls exposed to SSRI), 2025	Infant death (29–365 days after birth)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	12.57 [0.25;636.46] ^C excluded (control group)	0/117 0/1,465	0	117		ref
S18418 R77915	Lee (Controls unexposed, general pop), 2025	Infant death (29–365 days after birth)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	15.24 [0.94;246.37] ^C	0/117 130/463,440	130	117		ref
					Total	1 studies	15.24 [0.94;246.37]		130	117
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, general pop;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18443