Nortriptyline updated on 07-01-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11209
R41262		 Kjaersgaard (Controls unexposed, NOS), 2013 Spontaneous abortion (before 22 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: No Monotherapy: no or not specified 1.15 [0.82;1.61]
excluded (control group) 		-/-   -/983,258 - -
ref
S11210
R41263		 Kjaersgaard (Controls unexposed, sick), 2013 Spontaneous abortion (before 22 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.87 [0.42;1.80] -/-   -/- - -
ref
Total 1 studies 0.87 [0.42;1.80] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kjaersgaard (Controls unexposed, sick), 2013Kjaersgaard, 2013 1 0.87[0.42; 1.80]--0%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.87[0.42; 1.80]-- -NAKjaersgaard (Controls unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.87[0.42; 1.80]-- -NAKjaersgaard (Controls unexposed, sick), 2013 1 Tags Adjustment   - No  - No 0.87[0.42; 1.80]-- -NAKjaersgaard (Controls unexposed, sick), 2013 1 Monotherapy   - no or not specified  - no or not specified 0.87[0.42; 1.80]-- -NAKjaersgaard (Controls unexposed, sick), 2013 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.87[0.42; 1.80]-- -NAKjaersgaard (Controls unexposed, sick), 2013 1 All studiesAll studies 0.87[0.42; 1.80]-- -NAKjaersgaard (Controls unexposed, sick), 2013 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11209

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.15[0.82; 1.61]-- -NAKjaersgaard (Controls unexposed, NOS), 2013 1 unexposed, sick controlsunexposed, sick controls 0.87[0.42; 1.80]-- -NAKjaersgaard (Controls unexposed, sick), 2013 10.510.01.0