Doxepin updated on 07-01-2025

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11191
R42238		 Anderson, 2020 Major birth defects 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: TCA only 0.05 [0.00;1.04] C 0/3   30,630/42,105 30,630 3
ref
Total 1 studies 0.05 [0.00;1.04] 30,630 3
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.05[0.00; 1.04]30,63030%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.05[0.00; 1.04]30,6303 -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.05[0.00; 1.04]30,6303 -NAAnderson, 2020 1 Tags Adjustment   - No  - No 0.05[0.00; 1.04]30,6303 -NAAnderson, 2020 1 Monotherapy   - TCA only  - TCA only 0.05[0.00; 1.04]30,6303 -NAAnderson, 2020 1 All studiesAll studies 0.05[0.00; 1.04]30,6303 -NAAnderson, 2020 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.05[0.00; 1.04]30,6303 -NAAnderson, 2020 10.510.01.0