Citalopram updated on 07-01-2025

Cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18238
R76510		 Laspro, 2024 Isolated Cleft Palate (ICD-10 code Q35 excluding Q36 or Q37) during pregnancy (anytime or not specified) excluded nested case control unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.29 [1.05;1.57]
excluded (exposition period) 		97/-   5,762/- 5,859 -
ref
S7471
R22309		 Anderson, 2020 Cleft palate only 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.11 [0.47;2.64] -/-   0/- - -
ref
S8214
R25523		 Jordan, 2016 Cleft palate 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.84 [0.21;3.39] C
excluded (exposition period) 		2/4,028   298/506,155 300 4,028
ref
S6241
R16484		 Malm, 2011 Cleft palate 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 0.89 [0.33;2.41] -/2,799   -/628,607 - 2,799
ref
S6161
R16199		 Louik, 2007 Cleft palate alone 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 2.30 [0.40;12.60] 1/16   376/6,221 377 16
ref
Total 3 studies 1.12 [0.61;2.06] 377 2,815
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.11[0.47; 2.64]--50%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Malm, 2011Malm, 2011 0.89[0.33; 2.41]-2,79938%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Louik, 2007Louik, 2007 2.30[0.40; 12.60]3771612%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.12[0.61; 2.06]3772,8150.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.89[0.33; 2.41]-2,799 -NAMalm, 2011 1 case control studiescase control studies 1.28[0.59; 2.78]377160%NAAnderson, 2020 Louik, 2007 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.12[0.61; 2.06]3772,8150%NAAnderson, 2020 Malm, 2011 Louik, 2007 3 Tags Adjustment   - Yes  - Yes 1.12[0.61; 2.06]3772,8150%NAAnderson, 2020 Malm, 2011 Louik, 2007 3 Monotherapy   - no or not specified  - no or not specified 0.89[0.33; 2.41]-2,799 -NAMalm, 2011 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.11[0.47; 2.63]-- -NAAnderson, 2020 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 2.30[0.41; 12.91]37716 -NALouik, 2007 1 All studiesAll studies 1.12[0.61; 2.06]3772,8150%NAAnderson, 2020 Malm, 2011 Louik, 2007 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.12[0.61; 2.06]3772,8150%NAAnderson, 2020 Malm, 2011 Louik, 2007 30.510.01.0