Citalopram updated on 07-01-2025

Fetal distress

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7179
R20188		 Colvin, 2011 Fetal distress during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.40 [1.20;1.63] 205/1,136   12,673/92,995 12,878 1,136
ref
Total 1 studies 1.40 [1.20;1.63] 12,878 1,136
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2011Colvin, 2011 1.40[1.20; 1.63]12,8781,1360%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.40[1.20; 1.63]12,8781,136 -NAColvin, 2011 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.40[1.20; 1.63]12,8781,136 -NAColvin, 2011 1 Tags Adjustment   - No  - No 1.40[1.20; 1.63]12,8781,136 -NAColvin, 2011 1 Monotherapy   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.40[1.20; 1.63]12,8781,136 -NAColvin, 2011 1 All studiesAll studies 1.40[1.20; 1.63]12,8781,136 -NAColvin, 2011 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.40[1.20; 1.63]12,8781,136 -NAColvin, 2011 10.510.01.0