Citalopram updated on 07-01-2025

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7471
R22314		 Anderson, 2020 Anorectal atresia/stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.56 [0.61;3.99] -/-   0/- - -
ref
S6005
R15388		 Furu, 2015 Anal atresia 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.45 [0.64;3.25] 6/11,193   780/2,266,875 786 11,193
ref
S7351
R21507		 Wemakor, 2015 Ano-rectal atresia and stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.19 [0.29;16.63] 1/21   391/17,454 392 21
ref
S6161
R16202		 Louik, 2007 Anal atresia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 3.00 [0.30;28.20] 1/16   214/6,059 215 16
ref
Total 4 studies 1.61 [0.91;2.85] 1,393 11,230
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.56[0.61; 3.99]--37%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Furu, 2015Furu, 2015 1.45[0.64; 3.25]78611,19349%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Wemakor, 2015Wemakor, 2015 2.19[0.29; 16.63]392218%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Louik, 2007Louik, 2007 3.00[0.30; 28.20]215166%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (4 studies) I2 = 0% 1.61[0.91; 2.85]1,39311,2300.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.45[0.64; 3.27]78611,193 -NAFuru, 2015 1 case control studiescase control studies 1.78[0.80; 3.96]607370%NAAnderson, 2020 Wemakor, 2015 Louik, 2007 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.61[0.91; 2.85]1,39311,2300%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 Louik, 2007 4 Tags Adjustment   - Yes  - Yes 1.61[0.91; 2.85]1,39311,2300%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 Louik, 2007 4 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.54[0.86; 2.78]1,17811,2140%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 3   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 3.00[0.31; 29.09]21516 -NALouik, 2007 1 All studiesAll studies 1.61[0.91; 2.85]1,39311,2300%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 Louik, 2007 40.510.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-2.73.21.3910.000Anderson, 2020Furu, 2015Wemakor, 2015Louik, 2007

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.61[0.91; 2.85]1,39311,2300%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 Louik, 2007 40.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Zwink (Anorectal malformations)Zwink (Anorectal malformations) 1.68[0.82; 3.45]0%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT3 metaPregmetaPreg 1.61[0.91; 2.85]0%11,230----Anderson, 2020 Furu, 2015 Wemakor, 2015 Louik, 2007 40.510.01.0