Citalopram updated on 07-01-2025

Pulmonary valve stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7471
R22294		 Anderson, 2020 Pulmonary valve stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.79 [0.86;3.72] -/-   0/- - -
ref
S7351
R21518		 Wemakor, 2015 Pulmonary valve stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.22 [0.52;9.50] C 2/22   770/17,833 772 22
ref
Total 2 studies 1.87 [0.97;3.59] 772 22
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.79[0.86; 3.72]--80%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Wemakor, 2015Wemakor, 2015 2.22[0.52; 9.50]7722220%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.87[0.97; 3.59]772220.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.87[0.97; 3.59]772220%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.87[0.97; 3.59]772220%NAAnderson, 2020 Wemakor, 2015 2 Tags Adjustment   - No  - No 2.22[0.52; 9.50]77222 -NAWemakor, 2015 1   - Yes  - Yes 1.79[0.86; 3.72]-- -NAAnderson, 2020 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.87[0.97; 3.59]772220%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 1.87[0.97; 3.59]772220%NAAnderson, 2020 Wemakor, 2015 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.87[0.97; 3.59]772220%NAAnderson, 2020 Wemakor, 2015 20.510.01.0