Citalopram updated on 07-01-2025

Persistent pulmonary hypertension

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13120
R50017		 Marks (Controls exposed to Bupropion), 2021 Pulmonary Hypertension during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No 5.30 [0.25;110.77] C 2/385   0/406 2 385
ref
S6078
R15817		 Kieler, 2012 Persistent pulmonary hypertension of the newborn 2nd and/or 3rd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 2.30 [1.20;4.10] 11/3,294   1,935/1,588,140 1,946 3,294
ref
Total 2 studies 2.38 [1.30;4.34] 1,948 3,679
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Marks (Controls exposed to Bupropion), 2021Marks, 2021 1 5.30[0.25; 110.77]23854%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Kieler, 2012Kieler, 2012 2.30[1.20; 4.10]1,9463,29496%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.38[1.30; 4.34]1,9483,6790.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls exposed to Bupropion;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.38[1.30; 4.34]1,9483,6790%NAMarks (Controls exposed to Bupropion), 2021 Kieler, 2012 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.30[1.24; 4.25]1,9463,294 -NAKieler, 2012 1 exposed to other treatment, sickexposed to other treatment, sick 5.30[0.25; 110.77]2385 -NAMarks (Controls exposed to Bupropion), 2021 1 Tags Adjustment   - No  - No 5.30[0.25; 110.77]2385 -NAMarks (Controls exposed to Bupropion), 2021 1   - Yes  - Yes 2.30[1.24; 4.25]1,9463,294 -NAKieler, 2012 1 Monotherapy   - no or not specified  - no or not specified 2.30[1.24; 4.25]1,9463,294 -NAKieler, 2012 1 All studiesAll studies 2.38[1.30; 4.34]1,9483,6790%NAMarks (Controls exposed to Bupropion), 2021 Kieler, 2012 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.30[1.24; 4.25]1,9463,294 -NAKieler, 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 5.30[0.25; 110.77]2385 -NAMarks (Controls exposed to Bupropion), 2021 10.510.01.0