Citalopram updated on 07-01-2025

Large for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18431
R78046		 Lee (Controls exposed to TCAs), 2025 Large for gestational age (birth weight >2 standard deviations above the mean for gestational age) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.32 [0.62;8.61] C
excluded (control group) 		3/81   10/613 13 81
ref
S18412
R77783		 Lee (Controls unexposed, general pop), 2025 Large for gestational age (birth weight >2 standard deviations above the mean for gestational age) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.29 [0.40;4.11] 3/81   9,744/463,440 9,747 81
ref
S7696
R22827		 Kivistö, 2016 Large for gestational age (birthweight >10th centile) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.06 [0.67;1.69] -/215   2,191/24,402 - 215
ref
Total 2 studies 1.09 [0.71;1.67] 9,747 296
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 1.29[0.40; 4.11]9,7478114%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Kivistö, 2016Kivistö, 2016 1.06[0.67; 1.69]-21586%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.09[0.71; 1.67]9,7472960.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.09[0.71; 1.67]9,7472960%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.09[0.71; 1.67]9,7472960%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 Tags Adjustment   - Yes  - Yes 1.09[0.71; 1.67]9,7472960%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.09[0.71; 1.67]9,7472960%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 All studiesAll studies 1.09[0.71; 1.67]9,7472960%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18431

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.09[0.71; 1.67]11,9292960%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.32[0.62; 8.61]1381 -NALee (Controls exposed to TCAs), 2025 10.510.01.0