Bupropion (All indications except smoking cessation) updated on 07-01-2025

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13087
R49626		 Chun-Fai-Chan (Controls exposed to other antidepressants), 2005 Neonatal death (NOS) at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Indications Bupropion: Depression, mood or anxiety disorders Matched Monotherapy: no or not specified 2.40 [0.10;60.16] C
excluded (control group) 		1/72   0/57 1 72
ref
S13088
R49631		 Chun-Fai-Chan (Controls unexposed, NOS), 2005 Neonatal death (NOS) at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Bupropion: Any or not mentioned Matched Monotherapy: no or not specified 3.64 [0.15;90.25] C 1/105   0/126 1 105
ref
Total 1 studies 3.64 [0.15;90.25] 1 105
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chun-Fai-Chan (Controls unexposed, NOS), 2005Chun-Fai-Chan, 2005 1 3.64[0.15; 90.25]11050%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.64[0.15; 90.25]1105 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.64[0.15; 90.25]1105 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 Tags Adjustment   - No  - No 3.64[0.15; 90.25]1105 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 3.64[0.15; 90.25]1105 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 MatchedMatched 3.64[0.15; 90.25]1105 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 Monotherapy   - no or not specified  - no or not specified 3.64[0.15; 90.25]1105 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 All studiesAll studies 3.64[0.15; 90.25]1105 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13087

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.64[0.15; 90.25]1105 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.40[0.10; 60.16]172 -NAChun-Fai-Chan (Controls exposed to other antidepressants), 2005 10.510.01.0