Bupropion (All indications except smoking cessation) updated on 07-01-2025

Hypoplastic left heart (HLH/HLHS)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12927
R49047		 Anderson, 2020 Hypoplastic left heart syndrome 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Bupropion: Any or not mentioned Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.08 [0.82;5.28] -/-   0/- - -
ref
S12943
R49128		 Louik, 2014 Hypoplastic left heart syndrome 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Bupropion: Any or not mentioned Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.00 [0.30;15.30] 1/20   280/8,872 281 20
ref
Total 2 studies 2.07 [0.89;4.79] 281 20
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 2.08[0.82; 5.28]--82%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Louik, 2014Louik, 2014 2.00[0.30; 15.30]2812018%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 2.07[0.89; 4.79]281200.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.07[0.89; 4.79]281200%NAAnderson, 2020 Louik, 2014 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.07[0.89; 4.79]281200%NAAnderson, 2020 Louik, 2014 2 Tags Adjustment   - Yes  - Yes 2.07[0.89; 4.79]281200%NAAnderson, 2020 Louik, 2014 2 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 2.07[0.89; 4.79]281200%NAAnderson, 2020 Louik, 2014 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.07[0.89; 4.79]281200%NAAnderson, 2020 Louik, 2014 2 All studiesAll studies 2.07[0.89; 4.79]281200%NAAnderson, 2020 Louik, 2014 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.07[0.89; 4.79]281200%NAAnderson, 2020 Louik, 2014 20.510.01.0