Bupropion (All indications except smoking cessation) updated on 07-01-2025

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13149
R50204		 Marks (Controls exposed to Sertraline), 2021 5 Min APGAR <7 during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.95 [0.68;1.32] C 50/406   213/1,653 263 406
ref
Total 1 studies 0.95 [0.68;1.32] 263 406
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Marks (Controls exposed to Sertraline), 2021Marks, 2021 1 0.95[0.68; 1.32]2634060%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls exposed to Sertraline;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.95[0.68; 1.32]263406 -NAMarks (Controls exposed to Sertraline), 2021 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.95[0.68; 1.32]263406 -NAMarks (Controls exposed to Sertraline), 2021 1 Tags Adjustment   - No  - No 0.95[0.68; 1.32]263406 -NAMarks (Controls exposed to Sertraline), 2021 1 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 0.95[0.68; 1.32]263406 -NAMarks (Controls exposed to Sertraline), 2021 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.95[0.68; 1.32]263406 -NAMarks (Controls exposed to Sertraline), 2021 1 All studiesAll studies 0.95[0.68; 1.32]263406 -NAMarks (Controls exposed to Sertraline), 2021 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.95[0.68; 1.32]263406 -NAMarks (Controls exposed to Sertraline), 2021 10.510.01.0