Bupropion (All indications except smoking cessation) - Medication and Pregnancy KB

Bupropion (All indications except smoking cessation) updated on 07-01-2025

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13087 R49624	Chun-Fai-Chan (Controls exposed to other antidepressants), 2005	Stillbirths	at least 1st trimester	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No Indications Bupropion: Depression, mood or anxiety disorders Matched Monotherapy: no or not specified	0.98 [0.06;15.88] ^C excluded (control group)	1/91 1/89	2	91		ref
S13088 R49629	Chun-Fai-Chan (Controls unexposed, NOS), 2005	Stillbirths	at least 1st trimester	prospective cohort	unexposed (general population or NOS)	Adjustment: No Indications Bupropion: Any or not mentioned Matched Monotherapy: no or not specified	2.96 [0.12;73.21] ^C	1/136 0/133	1	136		ref
					Total	1 studies	2.96 [0.12;73.21]		1	136
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, NOS;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13087