Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Childhood autism (F84.0)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11782
R43354		 Sørensen - SNRI (Controls exposed to TCA), 2013 Childhood autism (ICD-10, codes ?) - At 4-14 years (mean 8.8 years) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No Monotherapy: TCA only 0.48 [0.04;5.26] C
excluded (control group) 		1/673   2/642 3 673
ref
S11783
R43355		 Sørensen - SNRI (Controls unexposed, NOS), 2013 Childhood autism (ICD-10, codes ?) - At 4-14 years (mean 8.8 years) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: SNRI only 0.47 [0.07;3.36] C 1/673   2,030/646,782 2,031 673
ref
Total 1 studies 0.47 [0.07;3.36] 2,031 673
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Sørensen - SNRI (Controls unexposed, NOS), 2013Sørensen - SNRI, 2013 1 0.47[0.07; 3.36]2,0316730%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.47[0.07; 3.36]2,031673 -NASørensen - SNRI (Controls unexposed, NOS), 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.47[0.07; 3.36]2,031673 -NASørensen - SNRI (Controls unexposed, NOS), 2013 1 Tags Adjustment   - No  - No 0.47[0.07; 3.36]2,031673 -NASørensen - SNRI (Controls unexposed, NOS), 2013 1 Monotherapy   - SNRI only  - SNRI only 0.47[0.07; 3.36]2,031673 -NASørensen - SNRI (Controls unexposed, NOS), 2013 1 All studiesAll studies 0.47[0.07; 3.36]2,031673 -NASørensen - SNRI (Controls unexposed, NOS), 2013 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11782

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.47[0.07; 3.36]2,031673 -NASørensen - SNRI (Controls unexposed, NOS), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.48[0.04; 5.26]3673 -NASørensen - SNRI (Controls exposed to TCA), 2013 10.510.01.0