Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Maternal consequences (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18440
R78221		 Lee (Controls exposed to TCAs), 2025 Any adverse obstetric outcomes (Induction of labour, cesarean delivery, premature rupture of membranes, postpartum haemorrhage, placental complications, ...) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: SNRI only 1.72 [0.90;3.29] C
excluded (control group) 		59/71   454/613 513 71
ref
S18441
R78242		 Lee (Controls unexposed, general pop), 2025 Any adverse obstetric outcomes (Induction of labour, cesarean delivery, premature rupture of membranes, postpartum haemorrhage, placental complications, ...) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: SNRI only 1.39 [0.75;2.60] 59/71   311,093/463,440 311,152 71
ref
Total 1 studies 1.39 [0.75;2.59] 311,152 71
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 1.39[0.75; 2.60]311,152710%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.39[0.75; 2.59]311,15271 -NALee (Controls unexposed, general pop), 2025 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.39[0.75; 2.59]311,15271 -NALee (Controls unexposed, general pop), 2025 1 Tags Adjustment   - Yes  - Yes 1.39[0.75; 2.59]311,15271 -NALee (Controls unexposed, general pop), 2025 1 Monotherapy   - SNRI only  - SNRI only 1.39[0.75; 2.59]311,15271 -NALee (Controls unexposed, general pop), 2025 1 All studiesAll studies 1.39[0.75; 2.59]311,15271 -NALee (Controls unexposed, general pop), 2025 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18440

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.39[0.75; 2.59]311,15271 -NALee (Controls unexposed, general pop), 2025 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.72[0.90; 3.29]51371 -NALee (Controls exposed to TCAs), 2025 10.510.01.0