Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11784
R43357		 Dandjinou - SNRI, 2019 Gestational diabetes mellitus during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SNRI only 1.27 [1.08;1.48] 230/1,894   20,675/228,059 20,905 1,894
ref
Total 1 studies 1.27 [1.08;1.49] 20,905 1,894
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dandjinou - SNRI, 2019Dandjinou - SNRI, 2019 1.27[1.08; 1.48]20,9051,8940%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.27[1.08; 1.49]20,9051,894 -NADandjinou - SNRI, 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.27[1.08; 1.49]20,9051,894 -NADandjinou - SNRI, 2019 1 Tags Adjustment   - Yes  - Yes 1.27[1.08; 1.49]20,9051,894 -NADandjinou - SNRI, 2019 1 Monotherapy   - SNRI only  - SNRI only 1.27[1.08; 1.49]20,9051,894 -NADandjinou - SNRI, 2019 1 All studiesAll studies 1.27[1.08; 1.49]20,9051,894 -NADandjinou - SNRI, 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.27[1.08; 1.49]20,9051,894 -NADandjinou - SNRI, 2019 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Wang - Venlafaxine (Gestational diabetes)Wang - Venlafaxine (Gestational diabetes) 1.29[1.11; 1.50]0%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 1.27[1.08; 1.49]NaN%1,894----Dandjinou - SNRI, 2019 10.510.01.0