Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18440
R78240		 Lee (Controls exposed to TCAs), 2025 Neonatal death (≤28 days after birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: SNRI only 8.69 [0.17;441.28] C
excluded (control group) 		0/71   0/613 0 71
ref
S18441
R78261		 Lee (Controls unexposed, general pop), 2025 Neonatal death (≤28 days after birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: SNRI only 5.23 [0.32;84.55] C 0/71   627/463,440 627 71
ref
Total 1 studies 5.23 [0.32;84.55] 627 71
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 5.23[0.32; 84.55]627710%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.23[0.32; 84.55]62771 -NALee (Controls unexposed, general pop), 2025 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.23[0.32; 84.55]62771 -NALee (Controls unexposed, general pop), 2025 1 Tags Adjustment   - No  - No 5.23[0.32; 84.55]62771 -NALee (Controls unexposed, general pop), 2025 1 Monotherapy   - SNRI only  - SNRI only 5.23[0.32; 84.55]62771 -NALee (Controls unexposed, general pop), 2025 1 All studiesAll studies 5.23[0.32; 84.55]62771 -NALee (Controls unexposed, general pop), 2025 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18440

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.23[0.32; 84.55]62771 -NALee (Controls unexposed, general pop), 2025 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 8.69[0.17; 441.28]-71 -NALee (Controls exposed to TCAs), 2025 10.510.01.0